The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary
predisposition and acquired molecular aberrations related to HB clinicopathological …

Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall
prognosis that has remained virtually unchanged for many decades. Currently, prevention or …

Targeting self-renewal is an important goal in cancer therapy and recent studies have
focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs) …

SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …