Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

Advances in genome sequencing have progressed at a rapid pace, with increased
throughput accompanied by plunging costs. But these advances go far beyond faster and …

Background Previous studies identified microRNAs (miRNAs) and messenger RNAs with
significantly different expression between normal pancreas and pancreatic cancer (PDAC) …

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …

High‐grade pancreatic intraepithelial neoplasia (HG‐PanIN) is the major precursor of
pancreatic ductal adenocarcinoma (PDAC) and is an ideal target for early detection. To …

Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …

Barrett's esophagus (BE) is a common disease in which the lining of the esophagus
transitions from stratified squamous epithelium to metaplastic columnar epithelium that …

The realization that cancer progression required the participation of cellular genes provided
one of several key rationales, in 1986, for embarking on the human genome project. Only …

Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions
and response to therapeutic treatments. We performed deep whole-genome sequencing …

We present an integrated approach that predicts and validates novel anti-cancer drug
targets. We first built a classifier that integrates a variety of genomic and systematic datasets …