In the developing brain, neural progenitor cells switch differentiation competency by
changing gene expression profiles that are governed partly by epigenetic control, such as …

VHL is mutated in the majority of patients with clear cell renal cell carcinoma (ccRCC), with
conflicting clinical relevance. Recent studies have identified recurrent mutations in histone …

Approximately 50% of patients with primary colorectal carcinoma develop liver metastases.
Understanding the genetic differences between primary colon cancer and their metastases …

Majority of clear cell renal cell carcinomas (ccRCCs) are diagnosed in the advanced
metastatic stage resulting in dramatic decrease of patient survival. Thereby, early detection …

Background Angiosarcomas (AS) are rare in humans, but they are a deadly subtype of soft
tissue sarcoma. Discovery sequencing in AS, especially the visceral form, is hampered by …

Pancreatic cancer is one of the main causes of cancer-related deaths worldwide. It is
asymptomatic at an early stage, and most diagnosis occurs when the disease is already at a …

The aim of this study was to identify pathways that have a significant impact during renal
carcinogenesis. Sixty‐seven paired samples of both noncancerous renal cortex tissue and …

Pancreatic cancer is an aggressive disease with a dismal prognosis in dire need of novel
diagnostic and therapeutic approaches. The past decade has witnessed an explosion of …

Clear cell renal cell carcinoma (ccRCC), the most common form of Kidney cancer, is
characterized by frequent mutations of the von Hippel-Lindau (VHL) tumor suppressor gene …

Genetic alterations in pancreatic tumors can usually be classified in:(1) Mutational activation
of oncogenes;(2) Inactivation of tumor suppressor genes; and (3) Inactivation of genome …