Pancreatic cancer is among the deadliest malignancies; however, the genetic events that
lead to pancreatic carcinogenesis in adults remain unclear. In vivo models in which these …

Background Genomic instability (GI) is a critical feature of cancer which plays a key role in
the occurrence and development of pancreatic adenocarcinoma (PAAD). Long non-coding …

Identifying driver mutations and their functional consequences is critical to our
understanding of cancer. Towards this goal, and because domains are the functional units of …

Background Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is an
aggressive malignancy associated with a low 5‐year survival rate. Poor outcomes …

CpG‐island methylator phenotype (CIMP)‐positive clear cell renal cell carcinomas (RCCs)
are characterized by accumulation of DNA hypermethylation of CpG islands …

Hepatocellular carcinoma (HCC) is one of the most common cancers with a dismal outcome.
The complicated molecular pathogenesis of HCC caused by tumor heterogeneity makes it …

Background Cancer genomes harbor hundreds to thousands of somatic nonsynonymous
mutations. DNA damage and deficiency of DNA repair systems are two major forces to …

The threatening notoriety of pancreatic cancer mainly arises from its negligible early
diagnosis, highly aggressive progression, failure of conventional therapeutic options and …

Simple Summary Although much progress has been made in recent years in the clinical
management of solid tumors, pancreatic ductal adenocarcinoma (PDAC) remains a …

Diffuse capillary malformation with overgrowth (DCMO) is a clinical diagnosis describing
patients with multiple, extensive capillary malformations (CMs) associated with overgrowth …