NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of
systems-level properties of cancer genes. In its current version, the database collects …

Background Pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal
papillary mucinous neoplasm (IPMN) is defined as PDAC occurring apart from IPMN. This …

Background To clarify the genetic mutations associated with intraductal papillary mucinous
neoplasms (IPMN) and IPMN-related pancreatic tumours, we conducted cancer-related …

Background DNA mismatch repair (MMR) defects are a major factor in colorectal
tumorigenesis in Lynch syndrome (LS) and 15% of sporadic cases. Some adenomas from …

Objectives The aims of this study were to identify the genetic mutations associated with
malignant intraductal papillary mucinous neoplasms (IPMNs) and evaluate the possibility of …

Background Clear cell renal clear cell carcinoma (ccRCC) is resistant to most
chemotherapeutic drugs and the molecular mechanisms have not been fully revealed …

Purpose Constitutional mismatch repair deficiency (CMMRD) is a highly penetrant cancer
predisposition syndrome caused by biallelic mutations in mismatch repair (MMR) genes. As …

With a 5-year survival rate of just 8%, pancreatic cancer (PC) is projected to be the second
leading cause of cancer deaths by 2030. Most PC patients are not eligible for surgery with …

The mismatch repair (MMR) system is indispensable for the fidelity of DNA replication, the
impairment of which predisposes to the development and progression of many types of …

Pancreatic cancer is one of the most aggressive human cancer types with a five-year
survival less than 7%. Emerging evidence revealed that many genetic alterations in …