Tumors of Lynch syndrome (LS) patients display high levels of microsatellite instability (MSI),
which results from complete loss of DNA mismatch repair (MMR), in line with Knudson's two …

Objective: Pancreatic cancer (PC) is an extremely malignant tumor with similar morbidity and
mortality and lack of an effective treatment. This study explored the prognostic value and …

The heterogeneity of cancer genomes in terms of acquired mutations complicates the
identification of genes whose modification may exert a driver role in tumorigenesis. In this …

Hereditary breast cancer accounts for 5–10% of all breast cancer cases. So far, known
genetic risk factors account for only 50% of the breast cancer genetic component and almost …

Like other solid tumors, colorectal cancer (CRC) is a genomic disorder in which various
types of genomic alterations, such as point mutations, genomic rearrangements, gene …

Colorectal cancer (CRC) genome is unstable and different types of instabilities, such as
chromosomal instability (CIN) and microsatellite instability (MSI) are thought to reflect distinct …

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Approximately
80% of patients initially diagnosed with locally advanced or metastatic disease survive only …

Over the last 10 years, next‐generation sequencing (NGS) has transformed genomic
research through substantial advances in technology and reduction in the cost of …

Pancreatic cancer is regarded as the most fatal and aggressive malignancy cancer due to its
low 5‐year survival rate and poor prognosis. The approaches of early diagnosis and …

Background & Aims Hepatocellular carcinoma develops in patients with chronic hepatitis or
cirrhosis via a stepwise accumulation of various genetic alterations. To explore the genetic …