Immunological and epigenetic changes are interconnected and contribute to tumorigenesis.
We determined the immunoprofiles and promoter methylation of inflammation-related genes …

Objectives The aims of this study were to identify genetic characteristics of intraductal
papillary mucinous neoplasm (IPMN)-associated pancreatic ductal carcinoma (PDC) and to …

The growth and advancement of ccRCC are strongly associated with the presence of
immune infiltration and the tumor microenvironment, comprising tumor cells, immune cells …

Although most sporadic colorectal cancers (CRC) are thought to develop from protruded
adenomas through the adenoma–carcinoma sequence, some CRC develop through flat …

Prime editing (PE), a recent progression in CRISPR-based technologies, holds promise for
precise genome editing without the risks associated with double-strand breaks. It can …

About 40% of clear‐cell renal cell carcinomas (ccRCC) harbour mutations in Polybromo‐1
(PBRM1), encoding the BAF180 subunit of a SWI/SNF chromatin remodelling complex. This …

Majority of colorectal cancer (CRC) patients are presented with advanced disease at
diagnosis, particularly in cases of proximal CRCs. Little is known about the relationship …

Ovarian cancer is a major cause of cancer deaths, yet there have been few known genetic
risk factors identified, the best known of which are disruptions in protein coding sequences …

Gene Symbol Description Associated diseases ABCB11 ATP-binding cassette, sub-family B
(MDR/TAP), member 11 Intrahepatic cholestasis ABCD1 ATP-binding cassette, sub-family D …

BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Variant
profiling is crucial for developing personalized treatment and elucidating the etiology of this …