Cancer has become one of the biggest problems, threatening the lives of many people every
day. There are a variety of strategies for the prevention, prognosis, control, and treatment of …

Cancer develops from a single cell with stepwise accumulation of genomic alterations.
Recent innovative sequencing technologies have made it possible to sequence the full …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with an overall 5-year
survival rate less than 5% due to the poor early diagnosis and lack of effective therapeutic …

Meiotic crossover recombination events are indispensable for proper chromosome
segregation and genetic information mixing. A better understanding of crossover …

Aims: The aim of Study I was to assess the effectiveness of chemotherapy for patients
withadvanced pancreatic cancer in a real-world setting. Study II aimed to evaluate the utility …

Despite the rapidly decreasing cost and increasing throughput of next-generation
sequencing technologies, deep targeted resequencing has maintained its importance in the …

Genome stability is tightly regulated through the cell cycle. Aberrations in genome structure
and sequence are a hallmark of malignancy and these changes can allow abnormal cells to …

Each year, over 2500 patients in Australia are diagnosed with pancreatic cancer. Pancreatic
cancer is one of the most lethal tumour types with a five year survival of just 5%, thus there is …

Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the
Western world and interactions between genetic and environmental factors, including diet …