Successful strategies for treating type 1 diabetes need to restore the function of pancreatic
beta cells that are destroyed by the immune system and overcome further destruction of …

Loss of functional β-cell mass is a hallmark of Type 1 and Type 2 Diabetes. Macrophages
play an integral role in the maintenance or destruction of pancreatic β-cells. The effect of the …

Diabetes mellitus can potentially be treated with islet transplantation, but additional sources
of β cells are necessary to overcome the short supply of donor pancreases. Although …

Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic
activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta …

Background/Aims: Elucidation of the molecular mechanisms underlying ovarian cancer (OC)
cell invasion and migration may provide important evidence for developing efficient therapy …

Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent
metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) …

Genetic manipulations, with or without lineage tracing for specific pancreatic cell types, are
very powerful tools for studying diabetes, pancreatitis and pancreatic cancer. Nevertheless …

Previous studies have shown that metformin, an AMP-activated protein kinase activator
widely prescribed for type 2 diabetes, is especially beneficial in cases of diabetic retinopathy …

Neovascularization plays a substantial role in the regulation of invasion of glioblastoma.
However, the underlying molecular basis remains largely unknown. Both vascular …

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal primary
tumors in humans, with undetermined tumorigenesis. Although previous work by us, and by …