Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal primary
tumors in humans, with undetermined tumorigenesis. Although previous work by us, and by …

Endogenous reprogramming of pancreas-derived non-beta cells into insulin-producing cells
is a promising approach to treat type 1 diabetes (T1D). One strategy that has yet to be …

A role of adiponectin in tumorigenesis has recently been appreciated. Although plasma
adiponectin levels in subjects with prostate cancer have been found to be significantly lower …

Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for
the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically …

Background/Aims: Angiotensin converting enzyme 2 (ACE2) treatment suppresses the
severity of acute lung injury (ALI), through antagonizing hydrolyzing angiotensin II (AngII) …

Background/Aims: The current treatments fail to provide satisfactory cure for aggressive
prostate cancers (PCs). Hence, further comprehension of PC metastasis is highly …

Although antivascular endothelial growth factor a (VEGFa) treatment has been well applied
in cervical cancer therapy, the underlying molecular basis has not been precisely identified …

The malignancy of non-small cell lung cancer (NSCLC) is largely due to its invasion. Hence,
prevention of the cancer cell invasion, which is essentially regulated by vascular endothelial …

Recombinant adeno-associated virus (rAAV)-mediated gene delivery shows promise to
transduce the pancreas, but safety/efficacy in a neoplastic context is not well established. To …

Background/Aims: Age-related macular degeneration (AMD) appears to be a disease with
increasing incidence in Western countries and may develop into acquired blindness …