Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an
increasing urological disorder of human health, affecting about 12% of the world population …

Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can
lead to inflammation and subsequent renal failure, but the underlying pathological …

Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3
inflammasome, however, it remains unclear how crystals induce cell death. Here we report …

Background and aims Nephrolithiasis is a common renal disease with no effective
medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have …

The etiology of stone disease remains unknown despite the major technological advances
in the treatment of urinary calculi. Clinically, urologists have relied on 24-h urine collections …

Background Serum oxalate levels suddenly increase with certain dietary exposures or
ethylene glycol poisoning and are a well known cause of AKI. Established contributors to …

This study aimed to investigate the renal protective effect of atorvastatin (ATV) on the kidney
inflammation induced by calcium oxalate (CaOx) crystals. A cell model of cell‐crystal …

Aims This study was designed to reveal the role and underlying mechanism of excessive
autophagy mediated by ERS via the PERK-eIF2α pathway in the apoptosis and formation of …

The establishment of an experimental animal model would be useful to study the
mechanism of kidney stone formation. A calcium kidney stone model in rats induced by …

The cytotoxicity of calcium oxalate (CaOx) in renal epithelial cells has been studied
extensively, but the cell death mode induced by CaOx with different physical properties …