Background Combined oral contraceptives (COCs) have been associated with an increased
risk of arterial thrombosis, ie myocardial infarction or ischemic stroke. However, as these …

The safety of progestogens as a class has come under increased scrutiny after the
publication of data from the Women's Health Initiative trial, particularly with respect to breast …

Identifying interactions between known drugs and targets is a major challenge in drug
repositioning. In silico prediction of drug–target interaction (DTI) can speed up the expensive …

The polycystic ovary syndrome is one of the most common hormonal disorders affecting
women. It has multiple components—reproductive, metabolic, and cardiovascular—with …

This review comprises the pharmacokinetics and pharmacodynamics of natural and
synthetic estrogens and progestogens used in contraception and therapy, with special …

The most recent studies of progesterone research provide remarkable insights into the
physiological role and clinical importance of this hormone. Although the name progesterone …

Background The risk of sudden death from cardiac causes in the general population peaks
from 6 am to noon and has a nadir from midnight to 6 am Obstructive sleep apnea is highly …

Osteoporosis is a metabolic bone disorder typified by a reduction in bone mass and
structural degradation of bone tissue, leading to heightened fragility and vulnerability to …

OBJECTIVE: This review discusses androgen status in male and female obesity, according
to their specific phenotype, and the main mechanisms responsible. DESIGN: Published data …

OBJECTIVES: The study was conducted to compare risks of adverse cardiovascular and
other events associated with the use of drospirenone (DRSP)-containing oral contraceptives …