Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

K Banik, E Khatoon, C Harsha, V Rana… - Phytotherapy …, 2022 - Wiley Online Library
The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or
Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots …

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

D Parama, M Boruah, K Yachna, V Rana, K Banik… - Life sciences, 2020 - Elsevier
Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

[HTML][HTML] Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy

L Liu, F Bai, H Song, R Xiao, Y Wang, H Yang, X Ren… - Redox Biology, 2022 - Elsevier
Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and
are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in …

Long non-coding RNA/epithelial-mesenchymal transition axis in human cancers: Tumorigenesis, chemoresistance, and radioresistance

M Hashemi, S Hajimazdarany, CD Mohan… - Pharmacological …, 2022 - Elsevier
Epithelial-to-mesenchymal transition (EMT) is a process that involves the transformation of
polarized epithelial cells to attain a mesenchymal phenotype that presents an elevated …

Non-coding RNAs and macrophage interaction in tumor progression

M Entezari, M Sadrkhanloo, M Rashidi, SE Asnaf… - Critical reviews in …, 2022 - Elsevier
The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor
malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage …

Per-and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters

JM Goodrich, MM Calkins, AJ Caban-Martinez… - …, 2021 - Taylor & Francis
Background: Per-and polyfluoroalkyl substances (PFASs) are persistent chemicals that
firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as …

Deep learning-based tumor microenvironment analysis in colon adenocarcinoma histopathological whole-slide images

Y Jiao, J Li, C Qian, S Fei - Computer Methods and Programs in …, 2021 - Elsevier
Abstract Background and Objective: Colon cancer is a fatal disease, and a comprehensive
understanding of the tumor microenvironment (TME) could lead to better risk stratification …

An integrated deep learning and molecular dynamics simulation-based screening pipeline identifies inhibitors of a new cancer drug target TIPE2

H Zhang, J Li, KM Saravanan, H Wu, Z Wang… - Frontiers in …, 2021 - frontiersin.org
The TIPE2 (tumor necrosis factor-alpha-induced protein 8-like 2) protein is a major regulator
of cancer and inflammatory diseases. The availability of its sequence and structure, as well …

Exploring connections between oral microbiota, short-chain fatty acids, and specific cancer types: a study of oral cancer, head and neck cancer, pancreatic cancer …

Z Nouri, SW Choi, IJ Choi, KW Ryu, SM Woo, SJ Park… - Cancers, 2023 - mdpi.com
Simple Summary Although there is strong evidence linking oral microbiota to several types
of cancer, the causal connections between them remain controversial. This study aims to …