Current approaches to the search for new kappa-opioid receptor (κ-OR) agonists with
potential analgesic activity are reviewed. Agents with peripheral activity and biased agonists …

Abstract Dynorphin A (Dyn A) is an endogenous opioid ligand that possesses
neuroinhibitory (antinociceptive) effects via μ, δ, and κ opioid receptors. However, under …

We report here the design and synthesis of novel multifunctional ligands that act as (μ/δ)
opioid agonists and bradykinin 2 receptor antagonists. These multifunctional ligands were …

Circumstantial evidences suggest that dynorphins and their common precursor
prodynorphin (PDYN) are involved in antinociception and neuroendocrine signaling …

Аннотация В обзорной статье представлены современные направления поиска
агонистов каппа опиоидных рецепторов (ОР) с потенциальной анальгетической …

摘要目的: 探讨Orexins 对小鼠摄食和能量代谢的影响. 方法: 将小鼠分为摄食组和代谢组,
摄食组通过中枢置管, 注射不同剂量(1, 3, 10 nmol) 的orexin-A 和orexin-B, 观察它们对小鼠摄食 …

Thymosinα1 is a peptidic hormone with pleiotropic activity, which is used in the therapy of
several diseases. It is unstructured in water solution and interacts with negative regions of …

It can be deduced from this concise review that bradykinin and polyphenols could have a
double role in health. Nevertheless, if their bioavailability is improved by their encapsulation …

As a unique endogenous opioid ligand, dynorphin A shows paradoxical neuroexcitatory
effects at bradykinin receptors, and the effects are known to be amplified by the upregulation …

Migraine is a prevailing type of neurological disorder and is frequently found coexisting with
temporomandibular disorders (TMD) in the same individual, especially in the patients with …