In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (ie,
electrical synapses) and the expression of the neuronal gap junction protein, connexin 36 …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

In less than a decade, a small family of channel-forming glycoproteins, named pannexins,
have captured the interest of many biologists, in large part due to their association with …

Abstract Pannexin 2 (Panx2) is a large-pore ATP-permeable channel with critical roles in
various physiological processes, such as the inflammatory response, energy production and …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …

Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …

Pannexins were originally thought to represent a second and redundant family of gap
junction proteins in addition to the well characterized connexins. However, it is now evident …

The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …

Methods such as electron microscopy and electrophysiology led to the understanding that
gap junctions were dense arrays of channels connecting the intracellular environments …