Transplantation of endothelial cells (ECs) holds great promise for treating various kinds of
ischemic diseases. However, the major challenge in ECs-based therapy in clinical …

The lack of vascularization limits the creation of engineered tissue constructs with clinically
relevant sizes. We pioneered a bottom-up process (modular tissue engineering) in which …

Stem cell-based therapy is currently tested in several trials of chronic heart failure. The main
question is to determine how its implementation could be extended to standard clinical …

Insights into the complex stem cell niche have identified the cell–material interface to be a
potent regulator of stem cell fate via material properties such as chemistry, topography and …

Stem cell-based myocardial regeneration therapies have emerged as alternative strategies
to heart transplantation for serious heart diseases, but autologous beating mature …

A stem cell in its microenvironment is subjected to a myriad of soluble chemical cues and
mechanical forces that act in concert to orchestrate cell fate. Intuitively, many of these …

Background Induced pluripotent stem cells (iPSC) can be differentiated to cells in all three
germ layers, as well as cells in the extraembryonic tissues. Efforts in iPSC differentiation into …

Fabrication techniques for cardiac tissue engineering have been evolving around scaffold-
based and scaffold-free approaches. Conventional fabrication approaches lack control over …

The need to source live human tissues for research and clinical applications has been a
major driving force for the development of new biomaterials. Ideally, these should elicit the …

Skeletal muscle tissue engineering is one of the important ways for regenerating functionally
defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a …