From 2006 to 2011, an average of 15 novel recombinant protein therapeutics have been
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …

Highlights•Glycosylation of antibodies has a range of effects on their binding and effector
functions.•Regulatory agencies require stringent glycan analysis to ensure safety and …

With the in-depth development of the market economy and the acceleration of the process of
urbanization, a large number of people have poured into the city, and a large number of …

Mammalian protein production platforms have had a profound impact in many areas of basic
and applied research, and an increasing number of blockbuster drugs are recombinant …

Monoclonal antibody (mAb) therapeutics are an effective modality for the treatment of
infectious, autoimmune, and cancer-related diseases. However, the discovery, development …

Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies
(mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio …

This article illustrates the basis and applications of methodologies for the analysis of simple
and complex carbohydrates by means of CE. After a description of the most common and …

Recombinant antibodies are rapidly developing therapeutic agents; approximately 40 novel
antibody molecules enter clinical trials each year, most of which are produced from Chinese …

Effective development of host cells for therapeutic protein production is hampered by the
poor characterization of cellular transfection. Here, we employed a multi-omics-based …

As CHO cell line development for biotherapeutic production becomes more sophisticated
through the availability of the CHO genome sequence, the ability to accurately and …