Importance Opioids are frequently prescribed to children and adolescents after surgery.
Prescription opioid misuse is associated with high-risk behavior in youth. Evidence-based …

BACKGROUND Recent national data are lacking on the prevalence, safety, and prescribers
of opioid prescriptions dispensed to children and young adults aged 0 to 21 years …

Objective To evaluate opioid prescribing, dispensing, and use in relation to hydrocodone-
containing product (HCP) rescheduling. Methods Seven biomedical databases and grey …

Background Pediatric umbilical hernia repair is a common procedure that requires minimal
tissue disruption. We examined variation in opioid prescription fills after repair of …

Background Prescription opioid abuse has become a major issue across the world and
especially in North America. Canada has the second highest number of opioid prescriptions …

Importance Practice guidelines recommend nonopioid medications in children after
tonsillectomy, but to date, studies have not used recent national data to assess perioperative …

Background: Cleft repair requires multiple operations from infancy through adolescence,
with repeated exposure to opioids and their associated risks. The authors implemented a …

Codeine and tramadol are opioid analgesics approved for the management of pain in the
United States. Both agents are metabolized in the liver to active compounds via the …

Administrative healthcare databases are created from records of service utilization and
payments for payer or hospital billing purposes. Such databases contain large amounts of …

Introduction Opioid dependence and abuse has been declared a national public health
emergency, and overprescribing of opioids after surgery has been identified as a driving …