During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …

Рабочая группа: академик РАН, профессор РГ Оганов (Председатель)(Москва),
академик РАН, профессор ИН Денисов (Председатель)(Москва), профессор ВИ …

Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

Sodium/glucose co‐transporter‐2 (SGLT2) inhibitors, which lower blood glucose by
increasing renal glucose elimination, have been shown to reduce the risk of adverse …

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

Background Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and
oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties …

Accumulating evidence suggests that asymptomatic hyperuricemia contributes to the
comorbidities with which it associates and that proper asymptomatic hyperuricemia …

The relationship between hyperuricemia, gout, and renal disease has been investigated for
several years. From the beginning, kidney disease has been considered a complication of …