Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Reproduction in mammals is an extremely energy-intensive process and is therefore tightly
controlled by the body's energy status. Changes in the nutritional status of the body cause …

Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r
gene), have well-established roles in stimulating reproduction via central actions on …

STUDY QUESTION Can kisspeptin treatment induce gonadotrophin responses and
ovulation in preclinical models and anovulatory women with polycystic ovary syndrome …

The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …

Background Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the
control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co …

Kisspeptin (encoded by Kiss1), a neuropeptide critically involved in neuroendocrine
regulation of reproduction, is primarily synthesized in two hypothalamic nuclei: the …