Adverse energy states exert a potent suppressive influence on the reproductive axis by
inhibiting the pulsatile release of gonadotrophin‐releasing hormone and luteinising …

Kisspeptin (encoded by Kiss1), a neuropeptide critically involved in neuroendocrine
regulation of reproduction, is primarily synthesized in two hypothalamic nuclei: the …

Obesity is associated with several female reproductive complications, such as polycystic
ovary syndrome (PCOS). The exact mechanism of this relationship remains unclear. Few …

Background Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the
control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co …

Kisspeptins (KPs) are proteins that were first recognized to have antimetastatic action. Later,
the critical role of this peptide in the regulation of reproduction was proved. In recent years …

Hypothalamic kisspeptin encoded by KISS1/Kiss1 gene emerged as a regulator of the
reproductive axis in mammals following the discovery of the kisspeptin receptor (Kissr) and …

Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence
indicates that kisspeptin is also important for body weight and metabolism, as whole-body …

Kisspeptin, a neuropeptide hormone, has been firmly established as a key regulator of the
hypothalamic–pituitary–gonadal axis and mammalian reproductive behaviour. In recent …

Context The hormone kisspeptin has crucial and well-characterized roles in reproduction.
Emerging data from animal models also suggest that kisspeptin has important metabolic …

Kiss1 neurons are essential regulators of the hypothalamic–pituitary–gonadal (HPG) axis by
regulating gonadotropin-releasing hormone (GnRH) release. Compelling evidence …