Chronic pain patients often develop mental disorders, and anxiety disorders are common.
We hypothesize that the comorbid anxiety results from an imbalance between the reward …

Peripheral and central sensitizations of the trigeminal nervous system are the main
mechanisms to promote the development and maintenance of chronic orofacial pain …

Empathic pain has attracted the interest of a substantial number of researchers studying the
social transfer of pain in the sociological, psychological, and neuroscience fields. However …

Background Chronic migraine is a common and highly disabling disorder. Functional MRI
has indicated that abnormal brain region activation is linked with chronic migraine. Drugs …

Behavioral responses to environmental stimuli are dictated by the affective valence of the
stimulus, good (positive valence) or bad (negative valence). These stimuli can innately elicit …

Heightened wakefulness in response to stressors is essential for survival but can also lead
to sleep disorders like insomnia. The paraventricular thalamus (PVT) is both a critical …

Pain that persists beyond the time required for tissue healing and pain that arises in the
absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood …

Depressive symptoms comorbid with chronic pain are a common health problem, but the
underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic …

Pain is a multifaceted process that encompasses unpleasant sensory and emotional
experiences. The essence of the pain process is aversion, or perceived negative emotion …

Background The neural circuitry underlying sevoflurane-induced modulation of
consciousness is poorly understood. This study hypothesized that the paraventricular …