Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Depressive symptoms are a customary finding in hospitalized patients, particularly those
who are undergoing long hospitalizations, underwent major surgical procedures or suffer …

A simple and efficient one-pot three-component synthetic route to highly substituted and
functionalizable piperazines in high yields with excellent stereoselectivity (de, ee> 99%) is …

Restless legs syndrome (RLS) is a chronic progressive movement disorder characterized by
abnormal sensations, especially at rest and at night, as the need and urge to move the lower …

This chapter focuses on the conviction that minimizing the time to the first dose in man (FIM)
is an important competitive advantage during drug development. The time from the first …

Summary Vortioxetine (Lu AA21004, 1‐[2‐(2, 4‐dimethylphenylsulfanyl) phenyl] piperazine,
Brintellix® or Trintellix®) is a multimodal serotonergic antidepressant that was approved by …