Exosomes: Therapy delivery tools and biomarkers of diseases
L Barile, G Vassalli - Pharmacology & therapeutics, 2017 - Elsevier
Virtually all cells in the organism secrete extracellular vesicles (EVs), a heterogeneous
population of lipid bilayer membrane-enclosed vesicles that transport and deliver payloads …
population of lipid bilayer membrane-enclosed vesicles that transport and deliver payloads …
[HTML][HTML] siRNA versus miRNA as therapeutics for gene silencing
JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
Ionizable lipid nanoparticle-mediated mRNA delivery for human CAR T cell engineering
Chimeric antigen receptor (CAR) T cell therapy relies on the ex vivo manipulation of patient
T cells to create potent, cancer-targeting therapies, shown to be capable of inducing …
T cells to create potent, cancer-targeting therapies, shown to be capable of inducing …
Orthogonal design of experiments for optimization of lipid nanoparticles for mRNA engineering of CAR T cells
Viral engineered chimeric antigen receptor (CAR) T cell therapies are potent, targeted
cancer immunotherapies, but their permanent CAR expression can lead to severe adverse …
cancer immunotherapies, but their permanent CAR expression can lead to severe adverse …
[HTML][HTML] Non viral vectors in gene therapy-an overview
M Ramamoorth, A Narvekar - Journal of clinical and diagnostic …, 2015 - ncbi.nlm.nih.gov
Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and
extracellular barriers, number of other challenges also needs to be overcome in order to …
extracellular barriers, number of other challenges also needs to be overcome in order to …
Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting
An intracellular delivery system for CRISPR/Cas9 is crucial for its application as a
therapeutic genome editing technology in a broad range of diseases. Current vehicles …
therapeutic genome editing technology in a broad range of diseases. Current vehicles …
[HTML][HTML] Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives
A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …
owing to their natural origin, their ability to mediate intercellular communication, and their …
[HTML][HTML] Recent progress on the versatility of virus-like particles
Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural
proteins of a virus in the absence of genetic material. Having similar morphology to natural …
proteins of a virus in the absence of genetic material. Having similar morphology to natural …
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and
nonimmunogenic delivery technologies must be developed. Here we show that exosomes …
nonimmunogenic delivery technologies must be developed. Here we show that exosomes …
Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived …
Exosomes are 40–100nm extracellular vesicles that are released from a multitude of cell
types, and perform diverse cellular functions including intercellular communication, antigen …
types, and perform diverse cellular functions including intercellular communication, antigen …