The timing of cellular events is inherently random because of the probabilistic nature of gene
expression. Yet cells manage to have precise timing of important events. Here, we study …

Cellular response to a stimulus is often triggered by accumulation of an appropriate gene
product up to a critical threshold. How cells regulate gene expression to achieve precision in …

Different expression vectors are available for the effective production of recombinant
proteins by bacterial populations. However, the productivity of such systems is limited by the …

In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

Phosphorelays are signal transduction circuits that combine four different phosphorylatable
protein domains for sensing environmental changes and use that information to adjust …

While time-dependent processes are important to biological functions, methods to leverage
temporal information from large data have remained computationally challenging. In …

At the level of individual living cells, key species such as genes, mRNAs, and proteins are
typically present in small numbers. Consequently, the biochemical reactions involving these …