Preclinical studies have been carried out during the past four decades to investigate the
different mechanisms of action of valproate (VPA). The mechanisms of VPA which seem to …

Valproate, one of the major antiepileptic drugs used today, has besides its wide use in both
generalized and partial epilepsies, several new approved indications including the …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Objective: We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the
treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant …

These updated guidelines are based on a first edition that was published in 2003, and have
been edited and updated with the available scientific evidence until end of 2008. Their …

The 2002 American Psychiatric Association (APA) guidelines for the treatment of bipolar
disorder recommended more conservative use of antidepressants. This change in …

Since the previous publication of Canadian Network for Mood and Anxiety Treatments
(CANMAT) guidelines in 1997, there has been a substantial increase in evidence‐based …

Bipolar disorders, including bipolar I disorder (BP-I) and bipolar II disorder (BP-II), are
common, potentially disabling, and, in some cases, life-threatening conditions. Bipolar …

Whereas much progress has been made in the diagnosis and treatment of schizophrenia
and depression in recent years, bipolar disorder continues to be frequently misunderstood …

Over the past twenty years, several lines of evidence from preclinical and clinical studies has
accumulated suggesting that a GABA deficit may be involved in mood disorders, particularly …