Enzymatic AND logic gates operated under conditions characteristic of biomedical applications

D Melnikov, G Strack, J Zhou… - The Journal of …, 2010 - ACS Publications
Experimental and theoretical analyses of the lactate dehydrogenase and glutathione
reductase based enzymatic AND logic gates in which the enzymes and their substrates …

Coupled oscillations and circadian rhythms in molecular replication networks

N Wagner, S Alasibi, E Peacock-Lopez… - The journal of …, 2015 - ACS Publications
Living organisms often display rhythmic and oscillatory behavior. We investigate here a
challenge in contemporary Systems Chemistry, that is, to construct “bottom-up” molecular …

De Novo Designed α‐Helical Coiled‐Coil Peptides as Scaffolds for Chemical Reactions

WM Rink, F Thomas - Chemistry–A European Journal, 2019 - Wiley Online Library
Coiled coils (CCs) are well‐understood protein‐folding motifs. They appear in a variety of
oligomer states and as homo‐and heteromeric assemblies. This versatility and the general …

Biochemical filter with sigmoidal response: Increasing the complexity of biomolecular logic

V Privman, J Halámek, MA Arugula… - The Journal of …, 2010 - ACS Publications
The first realization of a designed, rather than natural, biochemical filter process is reported
and analyzed as a promising network component for increasing the complexity of …

Elucidating the Origin of Diastereoselectivity in a Self‐Replicating System: Selfishness versus Altruism

A Dieckmann, S Beniken, CD Lorenz… - … A European Journal, 2011 - Wiley Online Library
We have investigated a diastereoselective self‐replicating system based on a cycloaddition
of a fulvene derivative and a maleimide using a two‐pronged approach of combining NMR …

Analog noise reduction in enzymatic logic gates

D Melnikov, G Strack, M Pita, V Privman… - The Journal of Physical …, 2009 - ACS Publications
In this work, we demonstrate both experimentally and theoretically that the analog noise
generation by a single enzymatic logic gate can be dramatically reduced to yield gate …

Bistability and bifurcation in minimal self‐replication and nonenzymatic catalytic networks

N Wagner, R Mukherjee, I Maity… - …, 2017 - Wiley Online Library
Bistability and bifurcation, found in a wide range of biochemical networks, are central to the
proper function of living systems. We investigate herein recent model systems that show …

Dynamic properties of a self-replicating peptide network with inhibition

LG Gagnon, ME Czaikowski… - The Journal of Chemical …, 2022 - pubs.aip.org
In this paper, we report an open system consisting of three self-replicating peptides, in which
peptide 1 inhibits the duplex template of peptide 2, peptide 2 inhibits duplex 3, and peptide 3 …

The emergence of halophilic evolutionary patterns from a dynamic combinatorial library of macrocyclic pseudopeptides

J Atcher, A Moure, I Alfonso - Chemical communications, 2013 - pubs.rsc.org
The emergence of halophilic evolutionary patterns from a dynamic combinatorial library of
macrocyclic pseudopeptides - Chemical Communications (RSC Publishing) DOI:10.1039/C2CC37869H …

Eros and logos

S Kauffman - Ontogenesis Beyond Complexity, 2021 - taylorfrancis.com
I wish to show that the becoming of the world is both entailed by the natural laws of physics
and is also a becoming beyond any law at all. Three hundred and thirty years after Newton …