Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Introduction Paracetamol is one of the most used medicines worldwide and is the most
common important poisoning in high-income countries. In overdose, paracetamol causes …

Acetaminophen (APAP)-induced liver injury (AILI) is a common liver disease in clinical
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …

Drug-induced liver injury (DILI) is a major clinical issue associated with the majority of
commercial drugs. During DILI, the peroxynitrite (ONOO–) level is upregulated in the liver …

Background & Aims Acetaminophen (APAP) overdose is a major cause of acute liver failure
(ALF). Mitochondrial SH3BP5 (also called SAB) and phosphorylation of c-Jun N-terminal …

As the metabolic and detoxification center of the body, the liver is closely involved in many
critical physiological processes, such as metabolism, immunity, digestion, storage of liver …

Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that
prescription and non-prescription drugs, herbal and dietary supplements can cause to the …

Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …

Paracetamol/Acetaminophen was widely used as a first-line antipyretic and analgesic for
COVID-19 patients without giving any attention to the potential risk of related toxicities. A …

Acute paracetamol (APAP) toxicity is a leading cause of liver, and less commonly renal,
injuries through oxidative stress and inflammation. Albeit vitamin D (VD) is a well-known anti …