Lung inflammation caused by inhaled toxicants: a review
Exposure of the lungs to airborne toxicants from different sources in the environment may
lead to acute and chronic pulmonary or even systemic inflammation. Cigarette smoke is the …
lead to acute and chronic pulmonary or even systemic inflammation. Cigarette smoke is the …
Phosphodiesterase-4 inhibitor therapy for lung diseases
Phosphodiesterases (PDEs) are a superfamily of enzymes that catalyze the breakdown of
cAMP and/or cyclic guanosine monophosphate (GMP) to their inactive form. PDE4 is the …
cAMP and/or cyclic guanosine monophosphate (GMP) to their inactive form. PDE4 is the …
What is asthma− COPD overlap syndrome? Towards a consensus definition from a round table discussion
Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS)
have been largely excluded from pivotal therapeutic trials and, as a result, its treatment …
have been largely excluded from pivotal therapeutic trials and, as a result, its treatment …
[HTML][HTML] Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity
Background As the multipotent progenitor population of the airway epithelium, human
airway basal cells (BC) replenish the specialized differentiated cell populations of the …
airway basal cells (BC) replenish the specialized differentiated cell populations of the …
Cigarette smoke activates NOTCH3 to promote goblet cell differentiation in human airway epithelial cells
M Bodas, AR Moore, B Subramaniyan… - American journal of …, 2021 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the
United States and is primarily caused by cigarette smoking. Increased numbers of mucus …
United States and is primarily caused by cigarette smoking. Increased numbers of mucus …
[HTML][HTML] Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway
K Gomi, V Arbelaez, RG Crystal, MS Walters - PloS one, 2015 - journals.plos.org
Airway basal cells (BC) function as stem/progenitor cells capable of differentiating into the
luminal ciliated and secretory cells to replenish the airway epithelium during physiological …
luminal ciliated and secretory cells to replenish the airway epithelium during physiological …
[HTML][HTML] Smoking accelerates aging of the small airway epithelium
MS Walters, BP De, J Salit, LJ Buro-Auriemma… - Respiratory …, 2014 - Springer
Background Aging involves multiple biologically complex processes characterized by a
decline in cellular homeostasis over time leading to a loss and impairment of physiological …
decline in cellular homeostasis over time leading to a loss and impairment of physiological …
SIRT 1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells
S Di Vincenzo, IH Heijink, JA Noordhoek… - Journal of cellular …, 2018 - Wiley Online Library
Inflammation and ageing are intertwined in chronic obstructive pulmonary disease (COPD).
The histone deacetylase SIRT 1 and the related activation of FoxO3 protect from ageing and …
The histone deacetylase SIRT 1 and the related activation of FoxO3 protect from ageing and …
[HTML][HTML] Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a/SIRT1/NF-κB pathway
X Zeng, X Yang, X Liu - Medicine, 2022 - journals.lww.com
Chronic obstructive pulmonary disease (COPD) is characterized by accelerated lung aging.
Smoking is the critical risk factor for COPD. Cellular senescence of airway epithelial cells is …
Smoking is the critical risk factor for COPD. Cellular senescence of airway epithelial cells is …
Central airways remodeling in COPD patients
L Pini, V Pinelli, D Modina, M Bezzi… - … journal of chronic …, 2014 - Taylor & Francis
Background The contribution to airflow obstruction by the remodeling of the peripheral
airways in chronic obstructive pulmonary disease (COPD) patients has been well …
airways in chronic obstructive pulmonary disease (COPD) patients has been well …