Major roles of kupffer cells and macrophages in NAFLD development

SJ Park, J Garcia Diaz, E Um, YS Hahn - Frontiers in Endocrinology, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is an important public health problem with growing
numbers of NAFLD patients worldwide. Pathological conditions are different in each stage of …

[HTML][HTML] The great potential of flavonoids as candidate drugs for NAFLD

L Li, Y Qin, X Xin, S Wang, Z Liu, X Feng - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of approximately 25%
and is associated with high morbidity and high mortality. NAFLD is a leading cause of …

Single-cell transcriptome analysis of liver immune microenvironment changes induced by microplastics in mice with non-alcoholic fatty liver

W Liu, M Li, H Guo, S Wei, W Xu, Y Yan, Y Shi… - Science of the Total …, 2024 - Elsevier
Recent studies have discovered that tiny particles of microplastics (MPs) at the nano-scale
level can enter the body of organisms from the environment, potentially causing metabolic …

NLRP3 inflammasome in acute and chronic liver diseases

K Sayaf, S Battistella, FP Russo - International Journal of Molecular …, 2024 - mdpi.com
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is an intracellular complex that
upon external stimuli or contact with specific ligands, recruits other components, forming the …

NOD-like receptors in the pathogenesis of metabolic (dysfunction)-associated fatty liver disease: Therapeutic agents targeting NOD-like receptors

S Khanmohammadi, B Ramos-Molina… - Diabetes & Metabolic …, 2023 - Elsevier
Background and aims In metabolic (dysfunction)-associated fatty liver disease (MAFLD),
activation of inflammatory processes marks the transition of simple steatosis to …

A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure

R Feng, Y Fan, X Zhang, L Chen, ZF Zhong, Y Wang… - ACS …, 2024 - ACS Publications
Acute liver failure (ALF) is a rare and serious condition characterized by major hepatocyte
death and liver dysfunction. Owing to the limited therapeutic options, this disease generally …

[HTML][HTML] Brown adipose tissue-derived Nrg4 alleviates non-alcoholic fatty liver disease in mice

J Luo, M Chen, H Ji, W Su, W Song, D Zhang… - Journal of Functional …, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease,
seriously affecting human health. Carnosine, which widely exists in the skeletal muscle of …

Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A …

L Huang, L Tan, Z Lv, W Chen, J Wu - Heliyon, 2024 - cell.com
Background Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition
with significant clinical implications. Emerging research indicates endoplasmic reticulum …

Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

Z Li, H Ouyang, J Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
MAFLD stands for metabolic-related fatty liver disease, which is a prevalent liver disease
affecting one-third of adults worldwide, and is strongly associated with obesity …

Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network …

S Li, X Wu, Y Ma, H Zhang, W Chen - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Erhuang Quzhi Granules (EQG) is a compound
composed of 13 traditional Chinese medicines developed by the First Affiliated Hospital of …