[HTML][HTML] T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
[PDF][PDF] IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
OS Blomberg, L Spagnuolo, H Garner, L Voorwerk… - Cancer Cell, 2023 - cell.com
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research
into the mechanisms underlying response to ICB has predominantly focused on T cells; …
into the mechanisms underlying response to ICB has predominantly focused on T cells; …
[HTML][HTML] Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
AM Tizazu, HM Mengist, G Demeke - Immunity & Ageing, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …
[HTML][HTML] The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy
J Rosenberg, J Huang - Current opinion in chemical engineering, 2018 - Elsevier
Highlights•CD8+ T cells and NK cells are both cytotoxic cells with engineering potential.•NK
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
Molecular architecture of the αβ T cell receptor–CD3 complex
ME Birnbaum, R Berry, YS Hsiao… - Proceedings of the …, 2014 - National Acad Sciences
αβ T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR
itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a …
itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a …
[PDF][PDF] Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance
In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of
developing T cells, generating central tolerance. Here, we investigate how developing T …
developing T cells, generating central tolerance. Here, we investigate how developing T …
[HTML][HTML] Coreceptors and TCR signaling–the strong and the weak of it
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …
development, but how they contribute to immune responses in the periphery is unclear …