Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Autoimmunity eventuates when the immune system attacks self-molecules as a result of the
breakdown in immune tolerance. Targeting autoimmune diseases via immunomodulation …

Vitiligo is the most common depigmenting disease characterized by achromic macules due
to selective loss of melanocytes. The pathogenesis remains poorly elucidated, and multiple …

The endoplasmic reticulum (ER) is the main site of protein synthesis, transport, and
modification. Its abnormal status has now emerged as an established cause of many …

Vitiligo is a chronic depigmenting disorder of the skin and mucosa caused by the destruction
of epidermal melanocytes. Although the exact mechanism has not been elucidated, studies …

The cytoplasmic replication of poxviruses requires extensive protein synthesis, challenging
the capacity of the endoplasmic reticulum (ER). However, the role of the ER in the life cycle …

Objective: Vitiligo is a common pigmentary disorder caused by the destruction of functional
melanocytes. Its immunopathogenesis is not completely understood, but inflammatory …