The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action

T Isa, E Marquez-Legorreta, S Grillner, EK Scott - Current Biology, 2021 - cell.com
The superior colliculus, or tectum in the case of non-mammalian vertebrates, is a part of the
brain that registers events in the surrounding space, often through vision and hearing, but …

Microbiota-brain interactions: Moving toward mechanisms in model organisms

J Nagpal, JF Cryan - Neuron, 2021 - cell.com
Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …

[HTML][HTML] A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

BK Hulse, H Haberkern, R Franconville… - Elife, 2021 - elifesciences.org
Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain

F Svara, D Förster, F Kubo, M Januszewski… - Nature …, 2022 - nature.com
Dense reconstruction of synaptic connectivity requires high-resolution electron microscopy
images of entire brains and tools to efficiently trace neuronal wires across the volume. To …

A cellular-resolution atlas of the larval zebrafish brain

M Kunst, E Laurell, N Mokayes, A Kramer, F Kubo… - Neuron, 2019 - cell.com
Understanding brain-wide neuronal dynamics requires a detailed map of the underlying
circuit architecture. We built an interactive cellular-resolution atlas of the zebrafish brain at 6 …

Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: From behavior to molecular mechanisms

JA Fitzgerald, S Könemann… - Environmental …, 2021 - Wiley Online Library
The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Imaging whole-brain activity to understand behaviour

A Lin, D Witvliet, L Hernandez-Nunez… - Nature Reviews …, 2022 - nature.com
Until now, most brain studies have focused on small numbers of neurons that interact in
limited circuits, allowing analysis of individual computations or steps of neural processing …

The roles of supervised machine learning in systems neuroscience

JI Glaser, AS Benjamin, R Farhoodi, KP Kording - Progress in neurobiology, 2019 - Elsevier
Over the last several years, the use of machine learning (ML) in neuroscience has been
rapidly increasing. Here, we review ML's contributions, both realized and potential, across …

Optical trapping in vivo: theory, practice, and applications

IA Favre-Bulle, AB Stilgoe, EK Scott… - …, 2019 - degruyter.com
Since the time of their introduction, optical tweezers (OTs) have grown to be a powerful tool
in the hands of biologists. OTs use highly focused laser light to guide, manipulate, or sort …

A connectomics-based taxonomy of mammals

LE Suarez, Y Yovel, MP van den Heuvel, O Sporns… - Elife, 2022 - elifesciences.org
Mammalian taxonomies are conventionally defined by morphological traits and genetics.
How species differ in terms of neural circuits and whether inter-species differences in neural …