Rethinking Click and Bioorthogonal Chemistry for Biomedical Applications

V Delplace - ACS Materials Letters, 2023 - ACS Publications
Over the last two decades, click chemistry and bioorthogonal chemistry have revolutionized
the field of biomedical engineering. Extensive investigations have been conducted and …

[HTML][HTML] Synthesis of multiple stimuli-responsive degradable block copolymers via facile carbonyl imidazole-induced postpolymerization modification

AM Jazani, JK Oh - Polymer Chemistry, 2022 - pubs.rsc.org
Smart block copolymers that exhibit degradability or reversibility in response to multiple
stimuli or environments (MSRD-exhibiting block copolymers) have been explored as …

Drug delivery systems based on renewable polymers: a conceptual short review

M Khodadadi Yazdi, K Jabbour… - Polymers from …, 2022 - journals.sagepub.com
There are ever increasing concerns about environmental and health hazards of
conventional synthetic polymers. These polymers are not sustainable because their …

Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers

H Zafar, B Liu, HVT Nguyen, JA Johnson - ACS Macro Letters, 2024 - ACS Publications
Controlling the access of proteases to cleavable peptides placed at specific locations within
macromolecular architectures represents a powerful strategy for biologically responsive …

Installing reduction responsiveness into biomolecules by introducing nitroaryl groups

SL Higashi, Y Shintani, M Ikeda - Chemistry–A European …, 2022 - Wiley Online Library
Artificially synthesized stimuli‐responsive biomolecules are attractive as molecular tools for
monitoring and modulating biological systems. In biological systems, redox stimuli are …

Clip‐off Chemistry: Synthesis by Programmed Disassembly of Reticular Materials

Y Yang, A Broto‐Ribas, B Ortín‐Rubio… - Angewandte …, 2022 - Wiley Online Library
Bond breaking is an essential process in chemical transformations and the ability of
researchers to strategically dictate which bonds in a given system will be broken translates …

[HTML][HTML] Controlled enzymatic synthesis of oligonucleotides

M Pichon, M Hollenstein - Communications Chemistry, 2024 - nature.com
Oligonucleotides are advancing as essential materials for the development of new
therapeutics, artificial genes, or in storage of information applications. Hitherto, our capacity …

Umpolung Isomerization in Radical Copolymerization of Benzyl Vinyl Ether with Pentafluorophenylacrylate Leading to Degradable AAB Periodic Copolymers

K Kuroda, M Ouchi - Angewandte Chemie International Edition, 2024 - Wiley Online Library
This study revealed that benzyl vinyl ether (BnVE) shows a peculiar isomerization
propagation in its radical copolymerization with an electron‐deficient acrylate carrying a …

Hydrogen Peroxide-Triggered Disassembly of Boronic Ester-Cross-Linked Brush-Arm Star Polymers

LC Costa, P Shieh, H Zafar, G Thiabaud… - ACS macro …, 2023 - ACS Publications
The concentrations of reactive oxygen species (ROS), eg, H2O2, are often elevated in
diseased tissue microenvironments. Therefore, the selective detection of ROS could enable …

Retrosynthetic Analysis Applied to Clip‐off Chemistry: Synthesis of Four Rh (II)‐Based Complexes as Proof‐of‐Concept

A Broto‐Ribas, S Ruiz‐Relaño, J Albalad… - Angewandte …, 2023 - Wiley Online Library
Clip‐off Chemistry is a synthetic strategy that our group previously developed to obtain new
molecules and materials through selective cleavage of bonds. Herein, we report recent work …