The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …

Tumor recurrence after the clinical cure of tumor often results from the presence of an
abnormal microenvironment, including an aberrant vasculature. The tumor …

Bromodomain and extraterminal domain proteins, especially bromodomain‑containing
protein 4 (Brd4), have recently emerged as therapeutic targets for several cancers, although …

This review describes the positive effects of growth hormone (GH) on the cardiovascular
system. We analyze why the vascular endothelium is a real internal secretion gland, whose …

A close association between pericytes and endothelial cells (ECs) is crucial to the stability
and function of capillary blood vessels and microvessels. The loss or dysfunction of …

Tendinopathy is the most common disorder in sports medicine. Multiple hypotheses have
been proposed for the aetiopathogenesis, but many aspects still remain elusive …

Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and the
most widely used model for ischemic retinopathies, such as retinopathy of prematurity …