We congratulate the KDIGO (Kidney Disease: Improving Global Outcomes) work group on
their comprehensive work in a broad subject area and agreed with many of the …

Introduction Adjusting doses of renally cleared medications and/or avoidance of nephrotoxic
medications are standard clinical practices in chronic kidney disease (CKD), albeit the …

Objectives To determine how many ambulatory older adults with chronic kidney disease
receive medications that are contraindicated or dosed excessively given their level of renal …

Increasing evidence suggests that antibiotic dosing in critically ill patients with acute kidney
injury (AKI) often does not achieve pharmacodynamic goals, and the continued high …

Infectious diseases are more prevalent in older people than in younger adults, and
represent a major healthcare issue in older populations. Indeed, infections in the elderly are …

Background: The antibiotic nitrofurantoin is commonly used to treat uncomplicated urinary
tract infections. However, when this drug is used by patients with reduced kidney function, its …

Introduction: Chronic kidney disease (CKD) is the progressive decline in renal function over
time. Patients with end-stage renal disease require renal replacement therapy such as …

Chronic kidney disease (CKD) has been a constant burden worldwide, with a prevalence of
more than 10% of the population and with mortality reaching 1.2 million deaths and 35.8 …

With advancing age, the functional reserve of many organs tends to decrease. In particular,
the lean body mass, the levels of serum albumin, the blood flow to the liver, and the …

Importance Population-based data are needed to inform the safe prescribing of
fluoroquinolone antibiotics to patients with advanced chronic kidney disease (CKD) …