In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …

Recent genomic studies have identified chromosomal rearrangements defining new
subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL), however many cases lack a …

Genomic analysis has greatly influenced the diagnosis and clinical management of patients
affected by diverse forms of hematologic malignancies. Here, we review how genetic …

Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted
therapy and detailed understanding of the genetic alterations driving leukemogenesis and …

Genomic events associated with poor outcome in chronic myeloid leukemia (CML) are
poorly understood. We performed whole-exome sequencing, copy-number variation, and/or …

Genomic classification has improved risk assignment of pediatric, but not adult B-lineage
acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (# …

Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood
cancer-related death. Prior studies have shown clonal mutations at relapse often arise from …

Acute lymphoblastic leukemia (ALL) is characterized by genetic alterations that block
differentiation, promote proliferation of lymphoid precursor cells, and are important for risk …