During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal
women worldwide and is characterized by reproductive, endocrine, and metabolic …

An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

STUDY QUESTION Do mitochondria-targeted therapies reverse ageing-and oxidative stress-
induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER Exposure …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

The prevalence of obesity is high among reproductive-age women and is associated with
impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity …

Mitochondria are highly dynamic organelles and their distribution, structure and activity
affect a wide range of cellular functions. Mitochondrial membrane potential (∆ Ψm) is an …