CRISPR modeling and correction of cardiovascular disease
Cardiovascular disease remains the leading cause of morbidity and mortality in the
developed world. In recent decades, extraordinary effort has been devoted to defining the …
developed world. In recent decades, extraordinary effort has been devoted to defining the …
Senescent cells at the crossroads of aging, disease, and tissue homeostasis
C Kuehnemann, CD Wiley - Aging Cell, 2024 - Wiley Online Library
Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …
In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …
Association of lonafarnib treatment vs no treatment with mortality rate in patients with Hutchinson-Gilford progeria syndrome
LB Gordon, H Shappell, J Massaro, RB D'Agostino… - Jama, 2018 - jamanetwork.com
Importance Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare fatal
premature aging disease. There is no approved treatment. Objective To evaluate the …
premature aging disease. There is no approved treatment. Objective To evaluate the …
Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome
E Beyret, HK Liao, M Yamamoto… - Nature medicine, 2019 - nature.com
Hutchinson–Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder
characterized by symptoms reminiscent of accelerated aging. The major underlying genetic …
characterized by symptoms reminiscent of accelerated aging. The major underlying genetic …
[HTML][HTML] Neurogenesis and brain aging
NK Isaev, EV Stelmashook… - Reviews in the …, 2019 - degruyter.com
Human aging affects the entire organism, but aging of the brain must undoubtedly be
different from that of all other organs, as neurons are highly differentiated postmitotic cells …
different from that of all other organs, as neurons are highly differentiated postmitotic cells …
[HTML][HTML] Phosphorylated lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria
LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the
nuclear periphery. Mutations in LMNA cause degenerative disorders including the …
nuclear periphery. Mutations in LMNA cause degenerative disorders including the …
Reproductive genetics and the aging male
AN Yatsenko, PJ Turek - Journal of Assisted Reproduction and Genetics, 2018 - Springer
Purpose To examine current evidence of the known effects of advanced paternal age on
sperm genetic and epigenetic changes and associated birth defects and diseases in …
sperm genetic and epigenetic changes and associated birth defects and diseases in …
Hutchinson–Gilford progeria syndrome
NJ Ullrich, LB Gordon - Handbook of clinical neurology, 2015 - Elsevier
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, uniformly fatal,
segmental “premature aging” disease in which children exhibit phenotypes that may give us …
segmental “premature aging” disease in which children exhibit phenotypes that may give us …
[HTML][HTML] Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse
S Osmanagic-Myers, A Kiss… - The Journal of …, 2019 - Am Soc Clin Investig
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder characterized
by accelerated cardiovascular disease with extensive fibrosis. It is caused by a mutation in …
by accelerated cardiovascular disease with extensive fibrosis. It is caused by a mutation in …