Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Post-translational modifications of connexins play an important role in the regulation of gap
junction and hemichannel permeability. The prerequisite for the formation of functional gap …

Methods such as electron microscopy and electrophysiology led to the understanding that
gap junctions were dense arrays of channels connecting the intracellular environments …

Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and
hemichannels (HCs). Only recently, specific tools have been developed to study their …

Gap junctions and hemichannels comprised of connexins influence epidermal proliferation
and differentiation. Significant advances in our understanding of the functional role of …

Hypertension is one of the most common risk factors for developing chronic cardiovascular
diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes …