Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain Injury

Y Yang, Z Li, X Fan, C Jiang, J Wang… - ACS …, 2024 - ACS Publications
Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently
emerged as promising candidates for treating ischemic stroke and traumatic brain injury …

Prussian blue nanotechnology in the treatment of spinal cord injury: application and challenges

XP Gu, SO Zhang, WH Ma - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Spinal cord injury (SCI) is a serious neurological condition that currently lacks effective
treatments, placing a heavy burden on both patients and society. Prussian blue …

Ginsenoside-Rh2 promotes functional recovery after spinal cord Injury by enhancing TFEB-Mediated autophagy

R Liu, L Jiang, Y Chen, J Shao, K Chen… - Journal of Agricultural …, 2024 - ACS Publications
Background: Following spinal cord injury (SCI), autophagy plays a positive role in neuronal
protection, whereas pyroptosis triggers an inflammatory response. Ginsenoside-Rh2 …

Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca2+ Homeostasis Regulation and Pancreas …

Y Wang, X Wang, X Zhang, B Zhang, X Meng, D Qian… - ACS …, 2024 - ACS Publications
Severe acute pancreatitis (AP) is a life-threatening pancreatic inflammatory disease with a
high mortality rate (∼ 40%). Existing pharmaceutical therapies in development or in clinical …

Spatiotemporally Controllable Bifunctional Micellar-Carbon Dot Supernanoparticles for Wounds Healing

L Chen, Z Hao, W Liu, F Zhang, H Zhang… - ACS Applied Nano …, 2024 - ACS Publications
Antimicrobial photodynamic therapy (aPDT) serves as a robust alternative to antibiotics,
effectively facilitating the healing of infected wounds and circumventing the risk of …

In situ photocrosslinkable hydrogel treats radiation-induced skin injury by ROS elimination and inflammation regulation

J Shen, W Jiao, J Yang, B Zhuang, S Du, Y Wu… - Biomaterials, 2024 - Elsevier
The clinical management of radiation-induced skin injury (RSI) poses a significant
challenge, primarily due to the acute damage caused by an overabundance of reactive …

Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization

R Qiao, Z Yuan, M Yang, Z Tang, L He… - Advanced …, 2024 - Wiley Online Library
Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of
radiation tolerance, immunosuppression and poor prognosis remains one of the critical …

Hollow mesoporous Prussian blue nanoenzymes as Rapamycin carrier for targeted treatment of ischemia/reperfusion-induced acute kidney injury through pro …

Y Wang, H Fu, B Huang, Z Liang, Y Shen… - Chemical Engineering …, 2024 - Elsevier
The kidney's abundant mitochondrial content and substantial oxygen requirements make it
particularly vulnerable to a series of detrimental events following ischemia/reperfusion (I/R) …

An esterase-activatable nanoprodrug mitigates severe spinal cord injury via alleviating ferroptosis and reprogramming inflammatory microenvironment

J Liu, Y Chang, W Zhou, S Rao, H Wang, R Lin, W Hu… - Nano Today, 2024 - Elsevier
Spinal cord injury (SCI) is a devastating condition with limited efficacious treatment options.
Recent research has revealed the potential of functional nanomedicines to inhibit ferroptosis …

CoNiCoNC tumor therapy by two-ways producing H2O2 to aggravate energy metabolism, chemokinetics, and ferroptosis

M Sun, Q Chen, Y Ren, Y Zhuo, S Xu, H Rao… - Journal of Colloid and …, 2025 - Elsevier
The effectiveness of chemokinetic therapy nanozymes is severely constrained because of
the low H 2 O 2 levels in the tumor microenvironment. Unlike other self-produced H 2 O 2 …