A healthy nutritional state is required for all aspects of reproduction and is signaled by the
adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little …

Leptin and ghrelin are two hormones that have been recognized to have a major influence
on energy balance. Leptin is a mediator of long‐term regulation of energy balance …

BACKGROUND: Convincing epidemiologic evidence links excess body mass to increased
risks of endometrial and postmenopausal breast cancers, but the relation between body …

Several factors such as age, gender, race, lifestyle and diet, contribute to the prevalence of
the metabolic syndrome, which has become the new epidemic of this century. They also …

Aging is accelerated when metabolic and cardiovascular diseases (CVD) are present and
the risk of these diseases increases with age. Many predisposing conditions which increase …

Adiponectin is secreted by the adipose tissue and is downregulated in states of obesity and
insulin resistance. There is a growing body of evidence indicating that adiponectin has …

The adipokine leptin signals the body's nutritional status to the brain, and particularly, the
hypothalamus. However, leptin receptors (LEPRs) can be found all throughout the body and …

Many factors regulate nervous system development, including complex cross-talk between
local neuroendocrine systems. The adipocyte-secreted hormone leptin, mainly known for its …

Leptin, the product of the obesity gene (ob) predominantly secreted from adipocytes, plays a
major role in the negative control of feeding and acts via a specific receptor (Ob‐R), six …

An fa allele of the leptin receptor gene (Leprfa) of the Zucker fatty rat was introduced into the
genome of the Spontaneously Diabetic Torii (SDT) rat, an inbred model of nonobese type 2 …