Atherogenesis, the formation of atherosclerotic plaques, is a complex process that involves
several mechanisms, including endothelial dysfunction, neovascularization, vascular …

Cardiovascular diseases claim more lives worldwide than any other. Etiologically, the
dominant trajectory involves atherosclerosis, a chronic inflammatory process of lipid-rich …

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues
from the Genotype-Tissue Expression project and genome-wide association study data …

The molecular mechanisms responsible for the development and progression of
atherosclerotic lesions have not been fully established. Here, we investigated the role …

The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …

Inflammation contributes to many of the characteristics of plaques implicated in the
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …

Vitamin D plays a classical hormonal role in skeletal health by regulating calcium and
phosphorus metabolism. Vitamin D metabolites also have physiological functions in …

Atherosclerosis is a chronic inflammatory disorder that is the underlying cause of most
cardiovascular disease. Both cells of the vessel wall and cells of the immune system …

Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner:
plaques grow in arteries until they block blood flow, causing acute coronary and other …

Objective—The biological mechanisms linking obesity to insulin resistance have not been
fully elucidated. We have shown that insulin resistance or glucose intolerance in diet …