Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …

Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …

The cell types that trigger the primary pathology in many brain diseases remain largely
unknown. One route to understanding the primary pathological cell type for a particular …

Decreased synaptic spine density has been the most consistently reported postmortem
finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of
many other genes with diverse functions, are strong-effect risk factors for autism spectrum …

Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in
vertebrate and invertebrate nervous systems. Prominent family members are the neural cell …

Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

Proteins belonging to the 'A Disintegrin And Metalloproteinase'(ADAM) family are membrane-
anchored proteases that are able to cleave the extracellular domains of several membrane …

Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …