Enhancing disease diagnosis: biomedical applications of surface-enhanced Raman scattering
Surface-enhanced Raman scattering (SERS) has recently gained increasing attention for
the detection of trace quantities of biomolecules due to its excellent molecular specificity …
the detection of trace quantities of biomolecules due to its excellent molecular specificity …
A double-blind, placebo-controlled comparator study of LY2140023 monohydrate in patients with schizophrenia
ACM Downing, BJ Kinon, BA Millen, L Zhang, L Liu… - BMC psychiatry, 2014 - Springer
Background Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly
selective agonist for the metabotropic glutamate mGluR2 and mGluR3 receptors. We …
selective agonist for the metabotropic glutamate mGluR2 and mGluR3 receptors. We …
[PDF][PDF] Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity
A Agarwal, M Zhang, I Trembak-Duff… - Cell reports, 2014 - cell.com
Summary Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for
schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased …
schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased …
Exosome transplantation from patients with schizophrenia causes schizophrenia-relevant behaviors in mice: an integrative multi-omics data analysis
Y Du, WL Tan, L Chen, ZM Yang, XS Li… - Schizophrenia …, 2021 - academic.oup.com
Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but the role of
exosomes in schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation of …
exosomes in schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation of …
DISC1 genetics, biology and psychiatric illness
PA Thomson, ELV Malavasi, E Grünewald… - Frontiers in biology, 2013 - Springer
Psychiatric disorders are highly heritable, and in many individuals likely arise from the
combined effects of genes and the environment. A substantial body of evidence points …
combined effects of genes and the environment. A substantial body of evidence points …
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons
Cognitive abilities and disorders unique to humans are thought to result from adaptively
driven changes in brain transcriptomes, but little is known about the role of cis-regulatory …
driven changes in brain transcriptomes, but little is known about the role of cis-regulatory …
Zbtb16 regulates social cognitive behaviors and neocortical development
Zinc finger and BTB domain containing 16 (ZBTB16) play the roles in the neural progenitor
cell proliferation and neuronal differentiation during development, however, how the function …
cell proliferation and neuronal differentiation during development, however, how the function …
The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
C Lavebratt, S Olsson, L Backlund, L Frisen… - Molecular …, 2014 - nature.com
The kynurenine pathway metabolite kynurenic acid (KYNA), modulating glutamatergic and
cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF) of patients with …
cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF) of patients with …
Molecular substrates of schizophrenia: homeostatic signaling to connectivity
MA Landek-Salgado, TE Faust, A Sawa - Molecular psychiatry, 2016 - nature.com
Schizophrenia (SZ) is a devastating psychiatric condition affecting numerous brain systems.
Recent studies have identified genetic factors that confer an increased risk of SZ and …
Recent studies have identified genetic factors that confer an increased risk of SZ and …
Demographically-based evaluation of genomic regions under selection in domestic dogs
AH Freedman, RM Schweizer… - PLoS …, 2016 - journals.plos.org
Controlling for background demographic effects is important for accurately identifying loci
that have recently undergone positive selection. To date, the effects of demography have not …
that have recently undergone positive selection. To date, the effects of demography have not …