Enhancing disease diagnosis: biomedical applications of surface-enhanced Raman scattering

M Chisanga, H Muhamadali, DI Ellis, R Goodacre - Applied Sciences, 2019 - mdpi.com
Surface-enhanced Raman scattering (SERS) has recently gained increasing attention for
the detection of trace quantities of biomolecules due to its excellent molecular specificity …

A double-blind, placebo-controlled comparator study of LY2140023 monohydrate in patients with schizophrenia

ACM Downing, BJ Kinon, BA Millen, L Zhang, L Liu… - BMC psychiatry, 2014 - Springer
Background Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly
selective agonist for the metabotropic glutamate mGluR2 and mGluR3 receptors. We …

[PDF][PDF] Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity

A Agarwal, M Zhang, I Trembak-Duff… - Cell reports, 2014 - cell.com
Summary Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for
schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased …

Exosome transplantation from patients with schizophrenia causes schizophrenia-relevant behaviors in mice: an integrative multi-omics data analysis

Y Du, WL Tan, L Chen, ZM Yang, XS Li… - Schizophrenia …, 2021 - academic.oup.com
Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but the role of
exosomes in schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation of …

DISC1 genetics, biology and psychiatric illness

PA Thomson, ELV Malavasi, E Grünewald… - Frontiers in biology, 2013 - Springer
Psychiatric disorders are highly heritable, and in many individuals likely arise from the
combined effects of genes and the environment. A substantial body of evidence points …

Human-specific histone methylation signatures at transcription start sites in prefrontal neurons

HP Shulha, JL Crisci, D Reshetov, JS Tushir… - PLoS …, 2012 - journals.plos.org
Cognitive abilities and disorders unique to humans are thought to result from adaptively
driven changes in brain transcriptomes, but little is known about the role of cis-regulatory …

Zbtb16 regulates social cognitive behaviors and neocortical development

N Usui, S Berto, A Konishi, M Kondo, G Konopka… - Translational …, 2021 - nature.com
Zinc finger and BTB domain containing 16 (ZBTB16) play the roles in the neural progenitor
cell proliferation and neuronal differentiation during development, however, how the function …

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression

C Lavebratt, S Olsson, L Backlund, L Frisen… - Molecular …, 2014 - nature.com
The kynurenine pathway metabolite kynurenic acid (KYNA), modulating glutamatergic and
cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF) of patients with …

Molecular substrates of schizophrenia: homeostatic signaling to connectivity

MA Landek-Salgado, TE Faust, A Sawa - Molecular psychiatry, 2016 - nature.com
Schizophrenia (SZ) is a devastating psychiatric condition affecting numerous brain systems.
Recent studies have identified genetic factors that confer an increased risk of SZ and …

Demographically-based evaluation of genomic regions under selection in domestic dogs

AH Freedman, RM Schweizer… - PLoS …, 2016 - journals.plos.org
Controlling for background demographic effects is important for accurately identifying loci
that have recently undergone positive selection. To date, the effects of demography have not …