Background Metastasis and drug resistance remain a persistent key clinical obstacle to the
success of breast cancer treatments. Recent years have seen an increased focus on …

Breast cancer brain metastasis is a major clinical challenge and is associated with a dismal
prognosis. Understanding the mechanisms underlying the early stages of brain metastasis …

Ovarian cancer is one of the most common gynecologic malignancies. It is characterized by
a high mortality rate, which is mainly due to the asymptomatic course of the disease. In light …

Matrix metalloproteinases (MMPs) are a group of enzymes that mediate both physiological
and pathological processes such as carcinogenesis. The role of matrix metalloproteinase-3 …

Abstract Background and Aims Breast cancer is a multifactorial malignancy with different
clinicopathological and molecular characteristics. It is the most frequent cancer in women in …

In the course of lung cancer, normal cells are transformed into cancerous ones, and
changes occur in the microenvironment, including the extracellular matrix (ECM), which is …

Simple Summary The dog is considered an animal model for the study of several diseases
that occur in humans since they present similar phenotypic development. Among them, we …

Abstract Background Extracellular vesicles (EVs), including microvesicles, hold promise for
the management of bladder urothelial carcinoma (BLCA), particularly because of their utility …

Proteolytic activity is perturbed in tumors and their microenvironment, and proteases also
affect cancer stem cells (CSCs). CSCs are the therapy-resistant subpopulation of cancer …

Prostate cancer (PCa) is the second most frequent and sixth most fatal cancer in men
worldwide. Despite its high prevalence, our understanding of its etiology and the molecular …