TRP Ion Channels in Immune Cells and Their Implications for Inflammation

Q Yan, C Gao, M Li, R Lan, S Wei, R Fan… - International Journal of …, 2024 - mdpi.com
The transient receptor potential (TRP) ion channels act as cellular sensors and mediate a
plethora of physiological processes, including somatosensation, proliferation, apoptosis …

Metabolic effects of CCL5 deficiency in lean and obese mice

H Zhou, X Liao, Q Zeng, H Zhang, J Song… - Frontiers in …, 2023 - frontiersin.org
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-
induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of …

Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis

H Li, T Pan, L Gao, R Ding, Y Yu, M Ma, Y Wang, S Jin… - Metabolism, 2024 - Elsevier
Abstract Background and aims Chemokine (Csingle bondC motif) receptor 1 (CCR1)
promotes liver fibrosis in mice. However, its effects on nonalcoholic steatohepatitis (NASH) …

[HTML][HTML] L-theanine relieves acute alcoholic liver injury by regulating the TNF-α/NF-κB signaling pathway in C57BL/6J mice

L Sun, S Wen, Q Li, X Lai, R Chen, Z Zhang, D Li… - Journal of Functional …, 2021 - Elsevier
Acute alcoholic liver injury (AALI) refers to the inflammatory hepatic damage caused by
alcohol. In severe cases, it can lead to steatohepatitis, alcoholic fibrosis and even cirrhosis …

Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy

W Lu, Y Xie, B Huang, T Ma, H Wang, B Deng… - Science Translational …, 2021 - science.org
Radiation proctopathy (RP) is characterized by inflammation of colorectal tissue and is a
common complication of radiation therapy for pelvic malignancies with high incidence but …

Effect of Europinidin against alcohol-induced liver damage in rats by inhibiting the TNF-α/TGF-β/IFN-γ/NF-kB/Caspase-3 signaling pathway

WA Mahdi, SA AlGhamdi, AM Alghamdi, SS Imam… - ACS …, 2023 - ACS Publications
Background: The effect of europinidin on alcoholic liver damage in rats was examined in this
research. Methods: A total of 24 Wistar rats were grouped in the same way into four groups …

Discovery of plasma biomarkers for predicting the severity of coronary artery atherosclerosis by quantitative proteomics

EJ Ku, KC Cho, C Lim, JW Kang, JW Oh… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction Cardiovascular disease (CVD) in patients with diabetes is the leading cause of
death. Finding early biomarkers for detecting asymptomatic patients with CVD can improve …

Hirsutidin protects against hepatic injury by alcohol-induced oxidative stress in mice

FA Al-Abbasi - Journal of Taibah University for Science, 2024 - Taylor & Francis
In this research, the influence of hirsutidin on mice with alcoholic liver disease was
examined. A total of 30 mice were randomly allocated to five groups (n= 6): Normal control …

[HTML][HTML] Protective effect of lyophilized sapodilla (Manilkara zapota) fruit extract against CCl4-induced liver damage in rats

ST Alrashood, AK Al-Asmari, AK Alotaibi… - Saudi Journal of …, 2020 - Elsevier
The tropical fruit sapodilla (Manilkara zapota syn. Achras zapota) is a rich source of
nutrients, minerals and a myriad of bioactive phytochemicals such as flavonoids and …

Granulocytic MDSC with deficient CCR5 alleviates lipogenesis and inflammation in nonalcoholic fatty liver disease

TC Liao, JP Huang, YT Tsai, WC Shih, CC Juan… - International Journal of …, 2022 - mdpi.com
CC chemokine receptor type 5 (CCR5) positively contributes to the pathogenesis of
nonalcoholic fatty liver disease (NAFLD), a common metabolic liver disease associated with …