Ibogaine is a hallucinogenic alkaloid, derived from Tabernanthe iboga, a plant unique to the
rainforests of West Africa. Its traditional use as an epiphanic sacrament in local magico …

In the present study, the effects of bilateral injections of N-methyl-d-aspartate (NMDA)
receptor agonist and/or antagonist into the central amygdala (CeA) on the acquisition and …

Antagonists of the N-methyl-D-aspartate (NMDA) receptor complex have been shown to
inhibit the expression of place preferences conditioned with several drugs that are abused …

Although opioids provide effective analgesia, largely unsubstantiated concerns about opioid-
induced tolerance, physical dependence and addiction have limited their appropriate use …

Excessive consumption of highly palatable food has been linked to the development of
eating disorders and obesity, and can be modeled in non-food-deprived rats by offering …

Morphine is widely used to treat chronic pain, however its utility is hindered by the
development of tolerance to its analgesic effects. While N-methyl-D-aspartate (NMDA) …

BACKGROUND: Preclinical findings suggest that the inhibition of NMDA glutamatergic
neurotransmission may have beneficial effects in the treatment of opioid dependence. AIMS …

N-Methyl-d-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is
thought to play a central role in the development of alcohol dependence and this alteration …

In thirteen of sixteen placebo‐controlled trials in Europe, acamprosate increased abstinence
in detoxified alcohol‐dependent patients. It is approved in most EU countries. Its action at N …

The pharmaceutical industry exploits traditional remedies for the development of new drugs,
especially chasing for unusual molecules with interesting and innovative mechanisms of …