PADI6: What we know about the elusive fifth member of the peptidyl arginine deiminase family

JPC Williams, LJ Walport - Philosophical Transactions of …, 2023 - royalsocietypublishing.org
Peptidyl arginine deiminase 6 (PADI6) is a maternal factor that is vital for early embryonic
development. Deletion and mutations of its encoding gene in female mice or women lead to …

New insights into oocyte cytoplasmic lattice-associated proteins

C Giaccari, F Cecere, L Argenziano, A Pagano… - Trends in Genetics, 2024 - cell.com
Oocyte maturation and preimplantation embryo development are critical to successful
pregnancy outcomes and the correct establishment and maintenance of genomic imprinting …

Clinical significance of FBXO43 in hepatocellular carcinoma and its impact on tumor cell proliferation, migration and invasion

R Ma, W Liu, T Sun, C Dang, K Li - PeerJ, 2023 - peerj.com
Background The effects of FBXO43 on hepatocellular carcinoma (HCC) and its clinical
significance have not yet been determined. This study aims to determine the clinical …

Intracellular fraction of zona pellucida protein 3 is required for the oocyte-to-embryo transition in mice

S Israel, J Seyfarth, T Nolte, HCA Drexler… - Molecular human …, 2023 - academic.oup.com
In oocyte biology, the zona pellucida has long been known to operate three extracellular
functions downstream of the secretory pathway, namely, encasing the oocytes in ovarian …

Gene expression and demographic analyses in women with the poor ovarian response: a computational approach

N Bahrami, A Nazari, Z Afshari, S Aftabsavad… - Journal of Assisted …, 2023 - Springer
Purpose Poor response to ovarian stimulation (POR) typically is reflected as decreased
follicular response and low estradiol (E2) levels following ovarian stimulation by FSH/HMG …

Genetic variants underlying developmental arrests in human preimplantation embryos

S Ozturk - Molecular Human Reproduction, 2023 - academic.oup.com
Developmental arrest in preimplantation embryos is one of the major causes of assisted
reproduction failure. It is briefly defined as a delay or a failure of embryonic development in …

High carrier frequency of pathogenic PATL2 gene mutations predicted in population: a bioinformatics-based approach

H Zhou, YL Cai, Q Luo, L Zou, YX Yin, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Topoisomerase II homologue 2 (PATL2) has been confirmed to be a key gene that
contributes to oocyte maturation. However, the allele distribution and carrier frequency of …

Identification of genomic characteristics and selective signals in Guizhou black goat

L Chang, Y Zheng, S Li, X Niu, S Huang, Q Long… - BMC genomics, 2024 - Springer
Background Guizhou black goat is one of the indigenous black goat breeds in the southwest
region of Guizhou, China, which is an ordinary goat for mutton production. They are …

Advances in the genetic etiology of female infertility

R Gu, T Wu, J Fu, YJ Sun, XX Sun - Journal of Assisted Reproduction and …, 2024 - Springer
Human reproduction is a complex process involving gamete maturation, fertilization, embryo
cleavage and development, blastocyst formation, implantation, and live birth. If any of these …

Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review

C Zhu, C Liu, Z Chai - Frontiers in Immunology, 2023 - frontiersin.org
The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of
isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can …