It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

The central nervous system (CNS) encompasses the brain and spinal cord and is
considered the processing center and the most vital part of human body. The central …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

The use of human pluripotent stem cells for in vitro disease modelling and clinical
applications requires protocols that convert these cells into relevant adult cell types. Here …

We review recent developments in the acute and long-term treatment of bipolar disorder and
identify promising future routes to therapeutic innovation. Overall, advances in drug …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

In vitro models of the human blood-brain barrier (BBB) are highly desirable for drug
development. This study aims to analyze a set of ten different BBB culture models based on …

Human pluripotent stem cells (hPSCs) have opened new opportunities for understanding
human development, modelling disease processes and developing new therapeutics …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …